作者：刘桂活，王荣昌，黄炯强

单位：广州医科大学附属第一医院 胃肠外科， 广东 广州 510120

Authors: Liu Guihuo，Wang Rongchang，Huang Jiongqiang

Unit: Gastrointestinal Surgery, the First Affiliated Hospital of Guangzhou Medical University，Guangzhou 510120，Guangdong，China

摘要：

胃肠道恶性肿瘤主要指胃癌和结直肠癌，是消化系统最常见的恶性肿瘤，也是排名前5位的最常见肿瘤，死亡率极高，严重威胁着人们的身体健康。对于晚期胃肠道肿瘤患者，免疫治疗或许是最后的治疗手段之一，其实际疗效仍有待进一步研究，随着免疫治疗的推广，不良反应的报道也愈发增多。本文通过对胃肠道肿瘤免疫治疗的现状研究，总结了目前常见的免疫治疗方案及常见不良事件，同时对其不良反应的处理及发生免疫治疗不良事件后的治疗选择进行总结。

关键词：胃肠道肿瘤； 胃癌； 结直肠癌； 免疫治疗； 免疫治疗相关不良事件

Abstract：

Gastrointestinal malignant tumor，mainly refers to gastric cancer and colorectal cancer is the most common malignant tumor of the digestive system ，and it is also the most common tumor in the top 5，with a high mortality rate and a serious threat to people's health. For patients with advanced gastrointestinal tumors，immunotherapy may be one of the last treatments，and its actual efficacy remains to be further studied. With the promotion of immunotherapy，the reports of its side effects are also increasing. Based on the study of the current situation of immunotherapy for gastrointestinal tumors ，this paper summarizes the common immunotherapy schemes and common adverse reactions ，as well as the treatment of adverse reactions and the choice of treatment after the occurrence of adverse reactions.

Key Words:  Gastrointestinal tumor; Gastric cancer; Colorectal cancer; Immunotherapy; Immunotherapy related adverse event