作者：贾哲，吴晓滨

单位：中山大学附属第八医院 胃肠外科，广东 深圳 518000

Authors:  Jia Zhe, Wu Xiaobin

Unit: Gastrointestinal Surgery, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518000, Guangdong, China

摘要：

肠道微生物群参与人类疾病的调控。随着宏基因组学和代谢组学技术的发展，肠道微生物群在癌症中的作用受到了研究者们的重视。相比于健康人群，不同癌症患者肠道微生物群的种类和丰度及其代谢产物存在差别，这提示我们可以借助肠道微生物群检测为癌症无创诊断提供更加敏感且易于被接受的新方法，以期实现癌症的早期诊断。不同的肠道微生物群和其代谢产物可能对肿瘤起着促进或抑制的作用，并且这一过程可能受到饮食尧吸烟等其他因素的影响。相比于健康人群，癌症患者的肠道微生物群发生了变化，而这些变化还可以影响癌症患者对化疗或免疫治疗的反应。靶向肠道微生物群为癌症的诊断和治疗提供了新的思路和方法。本文综述了肠道微生物群在癌症中的作用和机制研究进展。

关键词：肠道微生物；消化道肿瘤；肿瘤微环境

Abstract：

The intestinal microbiota is involved in the regulation of human disease. With the development of the metagenomics and metabonomics, the role of the intestinal microbiota in cancer has been valued by researchers. Compared with healthy people, there are differences in the types and abundance of intestinal microbial groups in different cancer patients and their metabolites, which suggests that we can use the intestinal microbial group test to provide more sensitive and easy to be accepted ways to achieve the early diagnosis of cancer. Different intestinal microorganisms and its metabolites may play different roles in promoting or suppressing the tumor, and this process may be affected by other factors such as diet and smoking. Compared with healthy people, the intestinal microorganisms of patients suffering from cancer have changed, and these changes can also affect the response of the patients to chemotherapy or immunotherapy. The intestinal microbiota provides new ideas and methods for the diagnosis and treatment of cancer. In this review, we have summarized the role and mechanism of the gut microbiota in cancer.

Key Words:  Intestinal microbiota; Gastrointestinal neoplasms; Tumor microenvironment