作者：陆冰啸1，龚晓宇2，邓杰3，郑金萍4，吴娜1，吕东津5，李云霞1

单位：1.昆明医科大学第三附属医院暨云南省肿瘤医院肿瘤内科，云南 昆明 650000；2.昆明理工大学附属医院暨云南省第一人民医院肝胆胰外科，云南 昆明 650000；3.昆明医科大学第三附属医院暨云南省肿瘤医院药学部，云南 昆明 650000；4.云南省陆良县培芳医院呼吸与危重症医学科，云南 陆良 655600；5.昆明医科大学第三附属医院暨云南省肿瘤医院 国家药物临床试验机构临床研究部，云南 昆明 650000

Authors: Lu Bingxiao1, Gong Xiaoyu2, Deng Jie3, Zheng Jinping4, Wu Na1, Lyv Dongjin5, Li Yunxia1

Unit:  1.Department of Medical Oncology, the Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming 650000, Yunnan, China；2.Department of Hepatopancreatobiliary Surgery, the Affiliated Hospital of Kunming University of Science and Technology (the First People's Hospital of Yunnan Province), Kunming 650000, Yunnan, China；3.Department of Pharmacy, the Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming 650000, Yunnan, China；4.Department of Pulmonary and Critical Care Medicine, the Peifang Hospital of Luliang, Luliang 655600,Yunnan, China；5.Department of Clinical Research, National Institute for Drug Clinical Trials, the Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming 650000, Yunnan, China

摘要：

食管癌是一种常见的上消化道肿瘤，最常见的组织类型为鳞状细胞癌和腺癌。近年来，随着微生物研究分析方法的进步，肠道微生物群在宿主生态系统中的作用以及机制得到了更全面的研究。肠道微生物群不仅在维持宿主健康方面发挥作用，在致癌和治疗反应预测中也发挥着关键作用。然而，针对肠道微生物群和肿瘤之间的研究更多地集中在黑色素瘤、结直肠癌、肺癌等癌种，关于食管癌的研究较为匮乏。因此，本文综述了近几年肠道微生物群在食管癌中的研究进展，并对肠道微生物群在肿瘤早筛早诊、治疗、监测和预防方面的发展趋势进行展望。

关键词： 肠道微生物群；食管癌；治疗反应；生物标志物

Abstract：

Esophageal cancer is a common tumor of the upper digestive tract, among which the most common histological subtypes are esophageal squamous cell carcinoma and esophageal adenocarcinoma. Recent advances in microbiological analysis methods have catalyzed a deeper understanding of complex hostmicrobe interactions and mechanism. Gut microbiome not only act as a role in maintaining host health, but also play a key role in carcinogenesis and therapeutic response prediction. However, studies on the relationship between gut microbiome and tumor focus more on melanoma, colorectal cancer, lung cancer and other cancers, while on esophageal cancer remain undetermined. Therefore, we reviewed the research progress of gut microbiome in esophageal cancer, and the development trend of gut microbiome in early screening, early diagnosis, treatment, monitoring and prevention of tumors were prospected.

Key Words:  Gut microbiome；Esophageal cancer；Therapy response；Biomarker

注：网络优先发布