引用文本：王威, 吴超, 梁一鸣, 等. 幽门螺杆菌感染对胃癌围手术期治疗及预后的影响[J/CD]. 消化肿瘤杂志（电子版）, 2026, 18(1): 152-162.

作者：王威，吴超，梁一鸣，任浩嵛，李泽群，周岩冰，曹守根

单位：青岛大学附属医院胃肠外科，山东 青岛 266000

Authors：Wang Wei, Wu Chao, Liang Yiming, Ren Haoyu, Li Zequn, Zhou Yanbing, Cao Shougen

Unit：Department of Gastrointestinal Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China

摘要：

幽门螺杆菌感染在全球范围内广泛存在，其全球感染率约为44.3%，被视为非贲门胃癌形成过程当中极为关键的致病因素。幽门螺杆菌借助毒力因子触发Correa级联反应，从而促进癌症的发生。根治性胃切除术联合辅助治疗已成为局部进展期胃癌的标准治疗策略。然而，胃癌术后幽门螺杆菌根除治疗的有效性及其与围手术期化学治疗、免疫治疗的协同效应尚未达成共识。现有临床指南明确指出，早期胃癌患者在接受内镜下黏膜切除术后，应进行幽门螺杆菌根除治疗，以减少术后复发的风险。然而，针对接受手术治疗的进展期胃癌患者，术后是否需要清除幽门螺杆菌以及何时进行清除，目前缺乏明确的结论。本文将系统阐述胃癌患者幽门螺杆菌对围手术期辅助治疗与免疫治疗疗效的影响以及术后根除幽门螺杆菌治疗的研究进展与未来的发展方向，旨在为临床实践提供科学依据和指导。

关键词：幽门螺杆菌；胃癌；胃切除术；根除治疗；自发清除

Abstract：

Helicobacter pylori (Hp) infection is prevalent worldwide, with a global prevalence rate of approximately 44.3%. Such an infection is considered a critically important pathogenic factor in the development of non-cardia gastric cancer. Hp triggers the Correa cascade reaction through its virulence factors, thereby promoting the occurrence of cancer. Radical gastrectomy combined with neoadjuvant and adjuvant therapy has become the standard treatment strategy for locally advanced gastric cancer. However, the effectiveness of Hp eradication treatment after gastric cancer surgery and its synergistic effect with perioperative chemotherapy and immunotherapy have not yet reached a consensus. The current clinical guidelines clearly state that for patients with early-stage gastric cancer who undergo endoscopic mucosal resection, Hp eradication therapy should be administered to reduce the risk of postoperative recurrence. However, for patients with advanced gastric cancer who have undergone surgical treatment, there is currently no clear conclusion regarding whether Hp needs to be eradicated after the surgery and when it should be done. This article will systematically elaborate on the impact of Hp in gastric cancer patients on the efficacy of perioperative adjuvant therapy and immunotherapy, as well as the research progress and future development direction of postoperative Hp eradication treatment. The aim is to provide scientific evidence and practical guidance for clinical practice.

Key words：Helicobacter pylori; Gastric cancer; Gastrectomy; Eradication therapy; Spontaneous clearance

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