作者：向松，陈剑辉

单位：中山大学附属第一医院胃肠外科，广东 广州 510080

Authors: Xiang Song, Chen Jianhui

Unit: Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China

摘要：

胃癌是全球最常见的恶性肿瘤之一，能快速浸润黏膜下层并具有极高的腹膜播散发生风险，常常导致不良的结局和较低的生活质量。胃癌的生物学行为与激酶水平密切相关，促进这些蛋白水平变化的信号通路正在被不断揭秘，相关的研究涉及病因、诊断、治疗和预后等各个方面。本文回顾了近年来胃癌磷酸化蛋白组学领域的相关文献，针对目前在临床诊治过程中遇到的难题，系统综述了其在促进胃癌精准医疗方面的应用前景。

关键词： 胃癌；磷酸化；蛋白组学；精准医疗

Abstract：

Gastric cancer is one of the most common malignant tumors in the world, with rapid infiltration of submucosa and a high risk of peritoneal dissemination, which often leads to adverse outcomes and low quality of life. The biological behavior of gastric cancer is closely related to the level of kinase, and the signal pathways that promote changes in these protein levels are constantly being revealed, and related studies involve etiology, diagnosis, treatment and prognosis. This paper reviews the relevant literatures in the field of gastric cancer phosphorylated proteomics in recent years, and systematically summarizes its application prospect in promoting gastric cancer precision medicine in view of the problems encountered in clinical diagnosis and treatment.

Key Words: Gastric cancer; Phosphorylation; Proteomics; Precision medicine