作者：沈亦敏1，李金洲1，李元元1，陈晓2

单位：1.兰州大学第二临床医学院, 甘肃 兰州 730000; 2.兰州大学第二医院 普通外科, 甘肃 兰州 730000

Authors: Shen Yimin1，Li Jinzhou1，Li yuanyuan1，Chen Xiao2

Unit: 1. Lanzhou University Second Hospital，Lanzhou 730000，Gansu，China; 2. General Surgery，Lanzhou University Second Hospital，Lanzhou 730000，Gansu，China

摘要：

近年，国内外学者对胃癌的预后因素进行了广泛研究，其中以非特异性炎症免疫标志物在胃癌中的研究较为集中。对可切除性胃癌患者来说，肿瘤相关巨噬细胞和肿瘤浸润淋巴细胞是研究的热点。肿瘤组织内浸润的肿瘤相关巨噬细胞越多，预后越差，相反，肿瘤浸润淋巴细胞越多则预后越好。此外，中性粒细胞与淋巴细胞比值、系统性免疫炎症指数、预后营养指数，这些炎症和免疫指标对行可切除性胃癌手术患者的预后也具有指导意义。有研究以这些指标为基础，通过可视化的列线图，对可切除性胃癌患者建立了高效的术后预测模型。今后，除了探讨这些指标在胃癌患者围手术期的动态变化对预后的影响价值，还要建立更高效能的预测模型，精确的预测可切除性胃癌患者的预后。

关键词：胃癌； 炎症； 肿瘤相关巨噬细胞； 系统性免疫炎症指数

Abstract：

In recent years，domestic and foreign scholars have carried out extensive research on the prognostic factors of gastric cancer. Among them，non -specific inflammatory markers and immune markers are the most concentrated in gastric cancer. For the patients of resectable gastric cancer ，tumor associated macrophages and tumor infiltrating lymphocytes have become a focus of research，the higher the density of tumor associated macrophages in the tumor issue，the worse the prognosis of patients. Conversely，the better the prognosis of patients with higher density of tumor infiltrating lymphocytes. Furthermore ，neutrophil lymphocyte ratio，systemic immune inflammatory index and prognostic nutritional index，which are immune and inflammatory markers，can also have guiding significance for the prognosis of patients undergoing resectable gastric cancer surgery. Some studies have established more effective postoperative prediction models for patients with resectable gastric cancer based on these markers through visual nomograms. In the future，in addition to exploring the prognostic value of the dynamic changes of these indicators in patients with gastric caner，it is also necessary to establish a more efficient prediction model to accurately predict the prognosis of patients with resectable gastric cancer.

Key Words:  Gastric cancer; Inflammatory; Tumor associated macrophages; Systemic immune inflammatory index