作者：林健梅1,3，韦丽丽1,3，王豪华2,3

单位：1.中山大学附属第六医院 临床检验科， 广东 广州 510655;  2.中山大学附属第六医院 放射肿瘤科， 广东 广州 510655;  3.广东省结直肠盆底疾病研究重点实验室， 广东 广州 510655

Authors: Lin Jianmei1,3，Wei Lili1,3，Wang Haohua2,3

Unit: 1.Department of Clinical Laboratory，The Sixth Affiliated Hospital，Sun Yat-Sen University，Guangzhou 510655，Guangdong，China;  2.Department of Radiation Oncology，The Sixth Affiliated Hospital，Sun Yat-Sen University，Guangzhou 510655，Guangdong，China;  3.Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases，The Sixth Affiliated Hospital，Sun Yat-Sen University，Guangzhou 510655，Guangdong，China

摘要：

早期结肠癌患者接受根治性手术治疗后仍有较高复发风险，一方面缺乏理想的术后监测手段，另一方面是治疗方式的局限性。随着液体活检技术的不断进步，通过检测患者血浆循环肿瘤DNA，可用于监测早期结肠癌的术后复发及指导术后辅助治疗。本文围绕血浆循环肿瘤DNA检测在早期结肠癌诊疗中的临床应用展开综述。

关键词：循环肿瘤DNA； 结肠癌； 辅助化疗

Abstract：

Patients with early-stage colon cancer still have a high chance of recurrence after radical surgery. It is due to the lack of ideal postoperative monitoring methods ，and the limitations of treatment methods. With the continuous advancement of liquid biopsy technology ，the detection of circulating tumor DNA （ctDNA） in patients' plasma can be used to monitor postoperative recurrence of early colon cancer and guide postoperative adjuvant therapy. This article reviews the clinical application of plasma ctDNA detection in the diagnosis and treatment of early colon cancer.

Key Words:  Circulating tumor DNA; Colon cancer; Adjuvant chemotherapy