作者：陈星1，姜泊2，迪吉1

单位：1.青海大学附属医院 肿瘤内科三病区， 青海 西宁 810001;  2.清华大学北京清华长庚医院 消化内科， 北京 100000

Authors: Chen Xing1，Jiang Bo2，Di Ji1

Unit: 1.Department of Oncology，Affiliated Hospital of Qinghai University，Xining 810001，Qinghai，China;  2.Department of Gastroenterology，Beijing Changgeng Hospital，Tsinghua University，Beijing 100000，China

摘要：

肿瘤的早发现、早诊断、早治疗是提高患者生活质量，降低死亡率、提高生存率的有效措施。筛查结直肠癌（CRC）需要准确的生物标志物，肠道菌群被认为是诊断早期CRC的可靠指标。肠道菌群检测是以粪便为样本，通过定量聚合酶链式反应对粪便细菌丰度进行定量。该方法具有标本采集简便，检查无侵入性风险、依从性高、特异度高等特点。通过肠道菌群对CRC的早期筛查，延长患者的生存时间、改变患者预后差的局面、提升我国对CRC的防控效果。

关键词：肠道菌群； 早期结直肠癌； 筛查

Abstract：

Early detection，diagnosis and treatment of tumors are effective measures to improve the quality of life，reduce mortality and improve survival rate of patients. Accurate biomarkers are needed to screen colorectal cancer. Intestinal flora is considered to be a reliable indicator for the diagnosis of early colorectal cancer. The detection of intestinal flora takes feces as samples and quantifies the abundance of bacterial feces by quantitative PCR. This method has the characteristics of simple sample collection ，no invasive risk，high compliance and specificity. Early screening of colorectal cancer by intestinal flora can improve the survival time of patients，change the poor prognosis of patients，and improve the prevention and control effect of colorectal cancer in China.

Key Words:  Intestinal flora； Early colorectal cancer； Screening