作者：马蕾，韩忠诚，柳江

单位：新疆维吾尔自治区人民医院 肿瘤科， 新疆 乌鲁木齐 830001

Authors: Ma Lei，Han Zhongcheng，Liu Jiang

Unit: Department of Oncology，People's Hospital of Xinjiang Uygur Autonomous Region，Urumqi 830001，Xinjiang，China

摘要：

目的 探讨胃肠道肿瘤患者维生素水平的流行病学特点，为临床制定防治措施提供依据。方法 选取2019年5月至2020年5月乌鲁木齐、伊犁、喀什胃肠道恶性肿瘤患者400例作为观察组，采用问卷调查、物理测量法统计患者信息资料，同期按1∶1选取新疆维吾尔自治区人民医院健康体检中心健康体检者400例作为对照组，对比两组维生素水平，分析胃肠道肿瘤患者维生素缺乏的流行病学特征。结果 400例胃肠道恶性肿瘤患者中维生素A缺乏占比30.25%(121/400)，维生素D缺乏占比71.50%(286/400)；不同年龄、饮酒情况、工作类型、糖尿病史、胃肠道肿瘤类型、TNM分期患者间维生素A水平比较，差异有统计学意义（P<0.05）；不同年龄、性别、体重指数（BMI）、腰臀比（WHR）、女性绝经史、饮酒情况、工作类型、运动频率、心脑血管病史、糖尿病史、胃肠道肿瘤类型、TNM分期间患者维生素D水平比较，差异有统计学意义（P<0.05）；经Logistic回归模型分析，年龄、饮酒情况、胃肠道肿瘤类型、TNM分期均是胃肠道肿瘤患者维生素A缺乏的危险因素（P<0.05）；年龄、性别、女性绝经史、饮酒情况、胃肠道肿瘤类型、TNM分期是胃肠道肿瘤患者维生素D缺乏的危险因素（P<0.05）。结论 乌鲁木齐、伊犁、喀什胃肠道肿瘤患者受年龄、生活习惯等多种因素影响，维生素A、维生素D缺乏情况严峻，临床在治疗中需结合上述影响因素注重胃肠道肿瘤患者维生素A、维生素D的补充。 

关键词：胃肠道肿瘤； 维生素； 流行病学

Abstract：

Objective Discuss the epidemiological characteristics of vitamin levels in patients with gastrointestinal tumors in Xinjiang，and provide a basis for clinical formulation of prevention and treatment measures. Method From May 2019 to May 2020，400 patients with gastrointestinal malignant tumors in Urumqi，Yili and Kashgar were selected as the observation group，questionnaire survey and physical measurement method were used to count patient information，and 400 cases of healthy physical examiners from Health Examination Center of People's Hospital of Xinjiang Uygur Autonomous Region were selected as the control group according to 1:1 during the same period，and the vitamin levels of the two groups were compared to analyze the epidemiological characteristics of vitamin deficiency in patients with gastrointestinal tumors. Result Vitamin A deficiency accounted for 30.25% （121/400） and vitamin D deficiency accounted for 71.50%（286/400） of 400 patients with gastrointestinal malignancies; There were statistically significant differences in vitamin A levels among patients of different ages，drinking status，type of work，history of diabetes，gastrointestinal tumor types，and TNM staging（P<0.05）;There were statistically significant differences in comparison of vitamin D levels among patients of different ages，genders，body mass index （BMI），waist-tohip ratio （WHR），women's menopausal history，drinking status，type of work，exercise frequency，history of cardiovascular and cerebrovascular diseases，history of diabetes，gastrointestinal tumor types，and TNM staging （P＜0.05）;After logistic regression model analysis，age，drinking status，gastrointestinal tumor type，and TNM staging are all related factors of vitamin A deficiency in patients with gastrointestinal tumors （P<0.05）;Age，gender，history of female menopause，alcohol consumption，gastrointestinal tumor types，and TNM staging are related factors of vitamin D deficiency in patients with gastrointestinal tumors（P<0.05）. Conclusion Urumqi，Ili，Kashgar gastrointestinal tumor patients affected by age，living habits and other factors，vitamin A，vitamin D deficiency is serious，clinical treatment needs to combine the above influencing factors to pay attention to vitamin A，vitamin D supplementation.

Key Words:  Gastrointestinal tumors; Vitamins; Epidemiology