作者：陆瑶，赵公芳，徐泉，张曦予

单位：昆明医科大学第二附属医院 消化内科，云南 昆明 650000

Authors:  Lu Yao, Zhao Gongfang, Xu Quan, Zhang Xiyu

Unit:  Digestive Medicine Department, the Second Affiliated Hospital of Kunming Medical College, Kunming 650000, Yunnan, China

摘要：

结直肠腺瘤性息肉(colorectal adenomatous polyps, CAP)是结直肠癌(colorectal cancer, CRC)的癌前病变,随着饮食习惯、生活方式的改变,CAP的发病率逐年上升。大多数CAP一般以"腺瘤-腺癌"发展,发现并控制CAP的危险因素和保护因素是降低CRC发病率的关键。CAP的发生与遗传、年龄、饮食习惯、肠道环境等多种因素相互作用有关,因此,深入研究CAP的危险因素,对降低CAP的发生具有重要意义。本文对CAP的相关因素和机制的研究进展进行一综述,以期通过控制CAP的相关因素降低CRC的发病率。

关键词：结直肠腺瘤性息肉；相关因素；相关机制；综述

Abstract：

Colorectal adenomatous polyps (CAPs) are recognized precancerous lesion of colorectal cancer (CRC). With the change of the diet and lifestyle, the incidence of CAP rise in recent years. Most of CAP will develop following a adenoma-cancer process. To find and control the risk factors and protective factors of CAP are the key to reduce the incidence of CRC. Research have shown that the occurrence of CAP is related to many factors such as genetic, age, diet and the intestinal environment interaction. Therefore, it is great significant for reducing the occurrence of CAP to research the risk factors of CAP deeply. In this paper, we summarize some advances of the research in the related factors and mechanism of CAP, in order to reduce the incidence of CRC.

Key Words:  Colorectal adenomatous polyps; Related factors; Related mechanism; Review