作者：杨力

单位：黑龙江中医药大学第一临床医学院， 黑龙江 哈尔滨 150006

Authors: Yang Li

Unit: First Clinical Hospital of Heilongjiang University of Chinese Medicine, Harbin 150006, Heilongjiang, China

摘要：

肿瘤细胞特有的代谢途径可以对肿瘤微环境内的生物小分子产生影响,而这些变化又可对局部免疫反应产生关键性的影响。肿瘤浸润淋巴细胞的代谢研究,已经为肿瘤的免疫治疗提供了可能的新策略。代谢限制已经在不同肿瘤中显示出了作为综合治疗的前景。本综述回顾了免疫代谢领域的一些最新研究进展,将在免疫检查点阻断、过继性细胞治疗和溶瘤病毒治疗等背景下,讨论抗肿瘤T细胞反应的代谢过程和内容。

关键词：肿瘤免疫治疗; 新陈代谢; 肿瘤微环境

Abstract：

The specific metabolic pathways of tumor cells can affect the small biological molecules in the tumor microenvironment, and these changes can have a key impact on the local immune response. The metabolic study of tumor infiltrating lymphocytes has provided a possible new strategy for tumor immunotherapy. Metabolic restriction has shown the prospect of comprehensive treatment in different tumors. In this review, we review some new developments in the field of immune metabolism, and discuss the metabolic process and content of antitumor T cell response under the background of immune checkpoint blocking, adoptive cell therapy and oncolytic virus therapy.

Key Words: Tumor immunotherapy; Metabolism; Tumor microenvironment