作者：李涛1,2，刘鹿3，陶然4，张帆1，胡毅1

单位：1. 中国人民解放军总医院 肿瘤医学部（全军肿瘤学重点实验室，肿瘤靶向治疗和抗体药物教育部重点实验室）， 北京 100853；2.中国人民解放军总医院/解放军医学院 研究生院， 北京 100853；3.中国人民解放军总医院 第一医学中心营养科， 北京 100853；4.中国人民解放军总医院 创新医学部转化医学中心， 北京 100853

Authors: Li Tao1,2，Liu Lu3，Tai Ran4，Zhang Fan1，Hu Yi1

Unit: 1.Department of Oncology, Chinese PLA General Hospital （301 Hospital）, （Chinese PLA Key Laboratory of Oncology, Key Laboratory for Tumor Targeting Therapy and Antibody Drugs （Ministry of Education））, Beijing 100853, China； 2.Graduate School, Chinese PLA General Hospital/Medical School of Chinese PLA, Beijing 100853, China； 3.Department of Nutrition, Chinese PLA General Hospital （301 Hospital）, Beijing 100853, China； 4.Center for Translational Medicine，Chinese PLA General Hospital （301 Hospital）, Beijing 100853, China

摘要：

胃癌具有早期不易被发现、侵袭度强、恶性程度高、远期生存不佳等特点,是世界范围内频发、高发和高死亡的恶性肿瘤,特别在中东地区和我国这一现状尤为突出。对于局部进展或晚期不可手术切除的胃癌患者而言,采取以化疗、放疗为主的全身综合治疗的控制手段非常有限。精准医学时代,随着对于癌症发生发展的分子机制和肿瘤免疫机制的逐步深入探索,相关靶向和免疫治疗药物对于胃癌的治疗逐步从"大水漫灌"走向"精准灌溉"时代。本文结合目前相关国内外研究进展并结合临床实际,对于局部进展或晚期不可手术切除胃癌的靶向治疗与免疫治疗和可能的生物标志物进行综述。

关键词：  胃癌和胃食管结合部腺癌; 靶向治疗; 免疫治疗

Abstract：

Gastric cancer （GC） as a malignant tumor with high morbidity and mortality worldwide, are particularly prominent in China and Middle East. At present, although chemotherapy, radiotherapy in treatment of inoperable locally advanced or metastatic gastric cancer have delayed the progress of the disease and improved the quality of life to some extent, more effective treatment and control methods are still lacking. In the era of precision medicine, with the gradual and in-depth exploration of the molecular mechanism of cancer occurrence and development and the tumor immune mechanism, the treatment of gastric cancer with relevant targeted and immunotherapy drugs has gradually changed from "flood irrigation" to "precision irrigation". In this paper, the targeted therapy and immunotherapy for locally advanced or advanced GC is reviewed based on the current research progress over the world.

Key Words: Gastric cancer; Targeted therapy; Immunotherapy