作者：龙双嫣，魏素菊

单位：河北医科大学第四医院 肿瘤内科，河北 石家庄 050011

Authors:  Long Shuangyan, Wei Suju

Unit:  Department of Medical Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China

摘要：

肠道微生物在肿瘤发生、发展及治疗过程中发挥着重要的作用。随着免疫治疗的兴起,肠道微生物在肿瘤免疫治疗中的作用及其作用机制也逐渐被大家认识。肠道菌群对免疫治疗疗效及其不良反应有重要影响,但肠道菌群数目庞大,在目前观察到的有益细菌中,双歧杆菌与人类免疫细胞相互作用并调节先天性和适应性免疫过程。随着对肿瘤免疫治疗的深入研究,双歧杆菌在免疫治疗中的作用也被逐渐发现。这为肿瘤免疫治疗提供了新的思路。

关键词：  肠道微生物; 双歧杆菌; 免疫治疗; 机制; 免疫相关不良反应

Abstract：

In recent years, we have realized that gut microbes play an important role in tumor occurrence, development and treatment. With the rise of immunotherapy, the role of gut microbes in tumor immunotherapy and its mechanism have gradually been recognized. Intestinal flora has an important impact on the efficacy of immunotherapy and its side effects. However, the number of intestinal flora is huge. Among the beneficial bacteria currently observed, Bifidobacterium have been shown to interact with human immune cells and regulate innate and the process of adaptive immunity. With the in-depth research on tumor immunotherapy, the role of Bifidobacterium in immunotherapy has been gradually discovered. This may provide new ideas for tumor immunotherapy.

Key Words:  Intestinal microorganisms; Bifidobacterium; Immunotherapy; Mechanisms; Immune related adverse events