作者：杨培伟，刘光伟，赵文霞

单位：河南中医药大学第一附属医院 脾胃肝胆科，河南 郑州450000

Authors: Yang Peiwei, Liu Guangwei, Zhao Wenxia

Unit: The Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China

摘要：

唾液酸结合免疫球蛋白样凝集素15（Siglec-15）是在巨噬细胞上表达的免疫抑制因子，在肿瘤相关巨噬细胞（TAM）介导的T 细胞免疫中发挥重要作用。Siglec-15 具有特殊的生物学特征，具有诱导肿瘤免疫逃逸的作用，并可调节肿瘤微环境（TME）免疫以及重置或重编码TME 中抗肿瘤免疫等方面的作用。本文就Siglec-15 影响恶性肿瘤免疫的研究进展综述如下。

关键词：Siglec-15； 生物学特征； 肿瘤免疫； 免疫逃逸； 肿瘤微环境

Abstract：

Sialic acid-binding immunoglobulin-like lectin 15 （Siglec-15） is an immunosuppressive factor expressed on macrophages and plays an important role in T-cell immunity mediated by tumor associated macrophage （TAM）. Siglec-15 has special biological characteristics, has the effect of inducing tumor immune escape, and can regulate the role of anti-tumor immunity in tumor microenvironment （TME）. In this paper, the research progress of Siglec-15 affecting malignant tumor immunity is summarized as follows.

Key Words:  Siglec-15; Biological characteristics; Tumor immunity; Immune escape; Tumor microenvironment