作者：甘钰1,2，袁方炜丹1,2，袁张凌1,2

单位：1.南昌大学第一附属医院 肿瘤科，江西 南昌 330000；2.南昌大学第一附属医院医学 创新中心，江西 南昌 330000

Authors: Gan Yu1,2，Fang Weidan1,2，Zhang Ling1,2

Unit: 1.Department of Medical Oncology, First Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi, China；2.Medical Innovation Center, First Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi, China

摘要：

环状RNAs (circRNAs)是一种新型的内源性非编码RNA,具有丰富性、稳定性、保守性和特异性等特点,可通过多种机制发挥生物学作用。circRNAs在结直肠癌(CRC)的发生发展中起到重要作用。随着高通量测序技术及蛋白组学的发展,人们不仅发现circRNAs具有编码蛋白的潜能,并且其编码的蛋白质与人类疾病的发生发展密切相关。因此,本文概述了circRNAs的形成、特性、生物学功能,并重点介绍了circRNAs的翻译起始机制及circRNAs通过翻译机制,在CRC中所发挥的作用。

关键词：环状RNAs; 结直肠癌; 蛋白翻译

Abstract：

As a new kind of RNA, circular RNAs （circRNAs） are endogenous non-coding RNA, which have the characteristics of universality, stability, conservatism and specificity, and can play a biological role through a variety of mechanisms. The study found that circRNAs play an important role in the development of colorectal cancer（CRC）. With the rapid development of high - throughput sequencing technology and proteomics, people have discovered that circRNAs can be translated into proteins, whose function is closely related to the occurrence and development of human diseases. Thus, in this review, we systematically summarize the biogenesis, features and biological functions of circRNAs, and highlight the translation initiation mechanism of circRNAs and the role of circRNAs in CRC through translation mechanism.

Key Words:  Circular RNA; Colorectal cancer; Protein translation