作者：刘薛萍1，张文兴2

单位：1.湖南中医药大学 研究生院，湖南 长沙 410208；2.湖南中医药大学第一附属医院 肝胆外科，湖南 长沙 410007

Authors: Liu Xueping1，Zhang Wenxing2

Unit: 1.Graduate School, Integrated Traditional Chinese and Western Medicine Clinical Specialty of Hunan Hunan University of Chinese Medicine，Changsha 410208，Hunan，China；2.Hepatobiliary Surgery，the First Hospital of Hunan University of Chinese Medicine，Changsha 410007，Hunan，China

摘要：

探讨恶性肿瘤与继发性骨质疏松之间相关性,提出对骨质疏松及其并发症防治相关方面的建议。对过去发表的有关恶性肿瘤伴继发性骨质疏松的文献进行了回顾,重点介绍了临床常见的恶性肿瘤与继发性骨质疏松相关的几个方面。这些文献阐述了继发性骨质疏松症与恶性肿瘤相关,以及许多具体的可能相关机制。目前已知恶性肿瘤和继发性骨质疏松关系主要有三种,广泛受到认可的关系是恶性肿瘤晚期骨转移所致的骨质疏松。在恶性肿瘤与继发性骨质疏松的相关性呈现出一些新的研究进展,不单单再局限于骨转移以后的状态,更多的关注点聚焦于医源性或恶性肿瘤本身。恶性肿瘤引起继发性骨质疏松症病因众多,了解其骨密度和潜在的骨折风险可能是癌症早期筛查要点,以及提高恶性肿瘤诱发继发性骨质疏松的风险意识是必要的,以方便提供早期的诊疗,延长生存期。

关键词：恶性肿瘤；骨质疏松；综述

Abstract：

To explore the correlation between malignant tumors and secondary osteoporosis, and to make recommendations on the prevention and treatment of osteoporosis and its complications. A review of the literature on malignant tumors with secondary osteoporosis published in the past was reviewed, focusing on several aspects related to clinically common malignant tumors and secondary osteoporosis. These documents describe the relationship between secondary osteoporosis and malignant tumors, and many specific possible related mechanisms. At present, there are three main known relationships between malignant tumors and secondary osteoporosis. A widely recognized relationship is osteoporosis caused by advanced bone metastasis of malignant tumors, and the relationship between malignant tumors and secondary osteoporosis. The correlation shows some new research progress, not only limited to the state after bone metastasis, but more attention is focused on iatrogenic or malignant tumors themselves . There are many causes of secondary osteoporosis caused by malignant tumors. Understanding its bone density and potential fracture risk may be the main points of early cancer screening, as well as raising awareness of the risk of secondary osteoporosis induced by malignant tumors. It is necessary to facilitate early diagnosis and treatment and prolong survival.

Key Words: Malignant tumor；Osteoporosis；Review