作者：汪雨彤1，叶凡1，张霄1，邹睿涵1，崔诗允2

单位：1.南京医科大学第一临床医学院，江苏 南京 211166

2.南京医科大学第一附属医院 肿瘤科，江苏 南京 210029

Authors: Wang Yutong1，Ye Fan1，Zhang Xiao1，Zou Ruihan1，Cui Shiyun2

Unit: 1.Nanjing Medical University, Nanjing 211166, Jiangsu, China；2.Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China

摘要：

结直肠癌作为全球三大常见恶性肿瘤之一,每年约有数百万例新病例产生。在生物免疫治疗的迅速发展下,免疫疗法为结直肠癌的治疗带来新的方案。肿瘤疫苗通过放大抗肿瘤免疫应答,激活患者体内特异性抗肿瘤反应,从而对肿瘤进行预防或治疗。本文就结直肠癌肿瘤疫苗的研制基础、临床研究进展以及疫苗开发遇到的挑战进行综述。

关键词：结直肠癌；肿瘤疫苗；研究进展；解决策略

Abstract：

Colorectal cancer is one of the three most common malignant tumors worldwide, with millions of new cases predicted each year. With the rapid development of biological immunotherapy, immunotherapy has brought new solutions to the treatment of colorectal cancer. Tumor vaccines can prevent or treat tumors by amplifying anti-tumor immune responses and activating specific anti-tumor responses in patients. Here, we conduct a comprehensive review concerning the advance of vaccine for colorectal cancer in preclinical and clinical research.

Key Words: Colorectal cancer；Tumor vaccine；Advance；Resolvent