作者：乔璐1,2，贾漪涛2

单位：1. 华北理工大学研究生院，河北 唐山 063210；2. 河北省人民医院 肿瘤三科,河北 石家庄 050051

Authors: Qiao Lu1, 2, Jia Yitao 2

Unit: 1.North China University of Science and Technology, Tangshan 063210, Hebei, China；2.Third Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, Hebei, China

摘要：

结直肠癌是常见的胃肠道肿瘤之一,与2型糖尿病等代谢疾病关系密切。二甲双胍作为2型糖尿病防治指南中推荐的一线用药,除了可以降低血糖外,还具有一定的抗肿瘤作用。近年来,二甲双胍在结直肠癌中的研究受到越来越多的关注。二甲双胍不仅可以通过多种机制抑制结直肠癌细胞的增殖、迁移及侵袭,还可以促进其凋亡。此外,它还可以增加结直肠癌对放疗的敏感性,克服化疗及靶向治疗的耐药性等。本文就此领域的研究进展展开综述。

关键词：二甲双胍，结直肠癌，治疗

Abstract：

Colorectal cancer is one of the common gastrointestinal tumors, which is closely related to metabolic diseases such as type 2 diabetes. Metformin is recommended as a first-line drug in the guidelines for the prevention and treatment of type 2 diabetes, which not only can reduce blood sugar, but also has an certain anti-tumor effect. In recent years, more and more attention has been paid to the study of metformin in colorectal cancer. It has been found that metformin can not only inhibit the proliferation, migration and invasion of colorectal cancer cells through a variety of mechanisms, but also promote their apoptosis. In addition, metformin can increase the sensitivity of colorectal cancer to radiotherapy and overcome the resistance to chemotherapy and targeted therapy. This article reviews the progress of this field.

Key Words: Metformin；Colorectal cancer；Treatment