作者：常钰玲，陈彻，刘芳，牛亚倩，赵川

单位：甘肃中医药大学 临床医学院，甘肃 兰州 730000

Authors:  CHANG Yuling, CHEN Che, LIU Fang, NIU Yaqian, ZHAO Chuan

Unit:  Gansu University of Chinese Medicine, School of Clinical Medicine, Lanzhou 730000, Gansu, China

摘要：

肝癌是世界上最常见的恶性肿瘤之一,并且发病率逐年增加,尤其是在中国。尽管关于肝癌生物代谢过程的研究越来越多,许多肿瘤抑制剂或癌基因的转录调控机制尚不清楚。微小RNA (MicroRNAs, miRNAs)是长约19～25个核苷酸的单链非编码RNA,可在转录后影响基因的表达和很多生物学过程,包括肝癌糖代谢。糖代谢受多种基因,分子形式的调节,本文从二个方面系统阐释微小RNA对肝癌细胞糖代谢的影响,并展望其在临床的应用。

关键词：  微小RNA; 肝癌; 糖代谢; 关键酶; 信号通路

Abstract：

Liver cancer is one of the most common malignant tumors in the world, and the incidence rate has increased year by year, especially in China. Although there are more and more studies on the biological metabolism of liver cancer, the transcription and regulation mechanism of many tumor inhibitors or oncogenes is still unclear. MicroRNA is a single-stranded non-coding RNA of about 19 to 25 nucleotides that can affect gene expression and many biological processes after transcription, including glucose metabolism of liver cancer. Glucose metabolism is regulated by various genes and molecular. This paper will explain the effects of miRNA on glucose metabolism in Hepatocellular carcinoma systematically from two aspects and looks forward to its clinical application.

Key Words:  MicroRNAs; Hepatocellular carcinoma; Glucose metabolism; Key enzymes; Signal pathway