作者：李文洁，商春雨，桑慧，周颖，朱宏

单位：南京医科大学第一附属医院 消化内科，江苏 南京 210029

Authors:  LI Wenjie, SHANG Chunyu, SANG Hui, ZHOU Ying, ZHU Hong

Unit:  Department of Gastroenterology, the First Affiliated Hospital With Nanjing Medical University, Nanjing 210029, Jiangsu, China

摘要：

研究发现糖尿病与包括肝癌、胰腺癌、结直肠癌、乳腺癌、膀胱癌等多种恶性肿瘤的发生及死亡风险相关。其病理生理学机制可能涉及到高血糖状态、高胰岛素血症、胰岛素抵抗、胰岛素生长因子-1途径的改变、氧化应激、增强的炎症过程以及类固醇激素的失调等。本文主要针对糖尿病与恶性肿瘤发生发展的相关性及其可能机制的相关研究进展进行综述。

关键词：  糖尿病; 恶性肿瘤; 相关性; 机制

Abstract：

Studies have founded that diabetes is associated with the developing risk of malignancies including liver, pancreatic, colorectal, breast and bladder cancer. Its pathophysiological mechanisms may be involved in hyperglycemia, hyperinsulinemia, insulin resistance, changes in the insulin growth factor-1 pathway, oxidative stress, enhanced inflammatory processes, and steroid hormone disorders. This article reviewed the correlation between diabetes and the development of malignant tumors. Also the possible mechanisms of malignant tumor progression caused by diabetes were analysised in this review.

Key Words:  Diabetes; Malignant Tumors; Correlation; Mechanisms