作者：李晟，余超，程元光，文刚

单位：安徽医科大学附属第三医院 胃肠外科，安徽 合肥 230061

Authors:  LI Sheng, YU Chao, CHENG Yuanguang, WEN Gang

Unit:  The Third Affiliated Hospital of Anhui Medical University, Department of Gastrointestinal Surgery, Hefei 230000, Anhui, China

摘要：

目的  探讨RAB31基因在胃癌中的表达及及其临床意义。方法  通过Oncomine数据库检索并分析RAB31基因在胃癌的各项研究中的表达情况。利用Kaplan-Meier Plotter对患者进行生存周期分析。结果  Oncomine数据库中共收集了455个不同肿瘤类型的研究结果,关于RAB31表达有统计学差异的结果共有78项,其中RAB31表达增高的研究有56项,表达降低的研究有22项。共有6项研究涉及RAB31在胃癌组织和在正常组织的表达,共包括458个样本,与对照组相比,RAB31在胃癌组织中高表达且差异具有统计学意义。利用Kaplan-Meier Plotter数据库分析RAB31表达对胃癌患者生存时间的影响发现,和低表达组相比,RAB3高表达组的胃癌患者的总生存时间显著降低且差异具有统计学意义。结论  RAB31基因在胃癌组织中高表达,且表达水平与患者预后相关。

关键词：  RAB31; 胃癌; Oncomine数据库

Abstract：

Objective  Explore the expression and significance of RAB31 in GS. Method  Using Oncomine database analyzed and extract the expression of RAB31 in gastric cancer. Using Kaplan-Meier Plotter database analyzed the prognostic roles of RAB31 in gastric cancer patients. Result  Oncomine database contained 455 studies involved in different types of tumors. The RAB31 expression was statistically significant in 78 studies, overexpressed in 56 studies and low-expressed in the other 22 studies. A total of 6 studies were involved RAB31 in gastric cancer tissues and normal tissues, including 458 samples, compare with normal tissues, the expression of RAB31 in gastric cancer tissue was significantly higher. Then using Kaplan Meier-Plotter database to analyze the prognostic roles of RAB31 in gastric cancer patients, we discover that high expression of RAB31 is closely associated with poor survival in gastric cancer compare with low expression. Conclusion  RAB31 was found highly expressed in gastric cancer tissues, and the expression level of RAB31 protein was correlated with the prognosis of gastric cancer.

Key Words:  RAB31; gastric cancer; Oncomine database