作者：潘娜1，舒磊2，胡洁琳1

单位：1.武汉市东湖医院 内三科，湖北 武汉 430074； 2.武汉市第一医院 消化内科，湖北 武汉 430022

Authors:  PAN Na1, SHU Lei2, HU Jielin1

Unit:  1.The third department of internal medicine, Wuhan donghu hospital, WuHan 430074, Hubei, China； 2.Department of Gastroenterology, Wuhan First Hospital, WuHan 430022, Hubei, China

摘要：

目的   探讨临床中应用复方消化酶与多潘立酮联合治疗老年功能性消化不良的临床疗效,并观察其对PG、G-17的影响。方法  研究将我院2017-01/2018-12间的120例老年功能性消化不良患者依据临床随机对照原则分组,即对照组与联合组,各60例。对照组给予常规多潘立酮治疗,联合组给予多潘立酮与复方消化酶联合治疗,观察两组的临床治疗效果。结果  联合组患者临床治疗总有效率93.33%,显著的高于对照组的75.00%,差异有统计学意义(P<0.05);两组患者治疗后的上腹胀、上腹痛、早饱和上腹部灼烧感的评分以及MTL、CRH、PG、G-17指标水平明显较治疗前有所改善,且临床数据值改善显示联合组优于对照组,比较有统计学意义(P<0.05)。结论  临床中对于老年功能性消化不良患者给予复方消化酶与多潘立酮联合治疗效果显著,能够提高临床疗效,并且改善PG、G-17指标水平,值得临床中应用推广。

关键词： 老年; 功能性消化不良; 多潘立酮; 复方消化酶; PG; G-17

Abstract：

Objective  To investigate the clinical efficacy of combined use of compound digestive enzyme and domperidone in the treatment of functional dyspepsia in the elderly, and to observe its effects on PG and G-17. Methods  120 elderly patients with functional dyspepsia between 2017-01/2018-12 were divided into groups according to the principle of clinical randomized control, namely, control group and combined group, 60 cases each. The control group was treated with conventional domperidone. The combination group was treated with domperidone and compound digestive enzymes to observe the clinical effects of the two groups. Results  The total effective rate of clinical treatment was 93.33%, which was significantly higher than that of the control group (75.00%). The difference was statistically significant (P<0.05). The upper and lower abdominal pain, upper abdominal pain and early saturated upper abdomen burn after treatment. The scores of burnt sensation and the levels of MTL, CRH, PG and G -17 were significantly improved compared with those before treatment, and the improvement of clinical data showed that the combined group was superior to the control group (P<0.05). Conclusion  Clinically, the combination of compound digestive enzyme and domperidone is effective in the treatment of elderly patients with functional dyspepsia. It can improve the clinical efficacy and improve the level of PG and G-17. It is worthy of clinical application.

Key Words:  Elderly; Functional dyspepsia; Domperidone; Compound digestive enzyme; PG; G-17