作者：徐钰婷1，李金2，熊文俊2，罗立杰2，郑燕生2，王玉颖1，朱晓峰1，薛玉玲1，罗思静1，肖芳蓉2，王伟2

单位：1. 广州中医药大学，广东 广州 510405； 2. 广州中医药大学第二附属医院/广东省中医院 胃肠外科，广东 广州 510120

Authors:  XU Yuting1, LI Jin2, XIONG Wenjun2, LUO Lijie2, ZHENG Yansheng2, WANG Yuying1, ZHU Xiaofeng1, XUE Yuling1, LUO Sijing1, XIAO Fangrong2, WANG Wei2

Unit:  1. Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China； 2. Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine/Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong, China

摘要：

目的   分析腹腔镜手术治疗>5 cm食管胃结合部胃肠间质瘤的临床疗效,探讨其安全性、可行性及临床应用价值。方法  回顾性分析2011年6月至2018年6月期间在广东省中医院收治的经病理证实为GIST的50例食管胃结合部GIST患者的临床资料。对比GIST大小≤5 cm(n=33)及>5 cm(n=17)的病人的相关信息,比较两组患者的短期疗效及长期预后。结果  两组病人在手术时间、出血量、术后并发症、术后离床活动时间、术后排气时间、术后全流饮食时间及术后住院时间的差异均无统计学意义(P>0.05)。中位随访时间为34(5～62)个月。两组的RFS(P=0.243,P>0.05)和OS(P=0.414,P>0.05)均无统计学意义。结论  腹腔镜手术治疗>5 cm食管胃结合部胃肠间质瘤是安全可行的。

关键词： 食管胃结合部; 胃肠间质瘤; 腹腔镜; 临床疗效

Abstract：

Objective  To analyse the quality and clinical efficacy of laparoscopic operation for the ＞5 cm gastrointestinal stromal tumor in esophagogastric junction, analyse its safety, feasibility and clinical value. Methods  The clinical data of 50 cases of gastrointestinal stromal tumor in esophagogastric junction performed laparoscopic surgery from June 2011 to June 2018 in Guangdong Provincial Hospital of Chinese Medicine were analyzed retrospectively. Short-term efficacy and long-term prognosis were compared between the size ≤5 cm (n=33) and ＞5 cm (n=17). Results  There was no significant difference of the operative time, blood loss, postoperative complication, postoperative1 ambulant time, time to first flatus, time to liquid diet intake and postoperative hospital stay between the two groups(P＞0.05). Among 50 cases, the media follow-up time was 34(5~62) months. There were no difference in the recurrence-free survival(P=0.243, P＞0.05) and overall survival (P=0.414, P＞0.05). Conclusion  Laparoscopic surgery for gastrointestinal stromal tumor in esophagogastric junction is safe and feasible.

Key Words:  Esophagogastric junction; Gastrointestinal stromal tumor; Laparoscopic; Clinical effect