作者：侯慧，刘慧敏，古再丽阿依▪阿不力孜，李炳雪，何思锐

单位：新疆医科大学第五附属医院 消化内科，新疆 乌鲁木齐 830011

Authors:  HOU Hui, LIU Huimin, ABULIZI Guzailiayi, LI Bingxue, HE Sirui

Unit:   Department of Gastroenterology, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang, China

摘要：

目的  探讨肿瘤标志物癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原724(CA724)和糖类抗原199(CA199)在评估胰腺癌治疗预后中的应用价值。方法  选取于2012年1月～2013年3月新疆医科大学第五附属医院首诊,并行手术治疗的胰腺癌患者46例,术后7 d、1个月和3个月采用放射免疫分析法检测肿瘤标志物CEA、CA724和CA199水平,分析以上三种肿瘤标志物在胰腺癌治疗预后质量评估中的应用效果。结果  血清CEA、CA724和CA199在不同分期胰腺癌患者中表达情况差异显著,均超过正常水平,且随着临床分期增高,血清表达水平逐渐增高,Ⅱ、Ⅲ期患者血清CEA、CA724和CA199表达水平明显高于Ⅰ期患者,数据比较差异有统计学意义(P<0.05);手术前,检测患者血清CEA、CA724和CA199水平明显高于正常值,手术治疗后7 d、1个月和3个月,患者各项指标水平明显低于治疗前,数据比较差异有统计学意义(P<0.05);术后3个月血清CEA、CA724和CA199水平正常者生存率更高,与各指标升高者相比差异有统计学意义(P<0.05)。结论  肿瘤标志物CEA、CA724和CA199水平可作为评估胰腺癌患者治疗预后质量的重要指标,为后续治疗方案制定提供参考依据,有进一步研究价值。

关键词： 肿瘤标志物; 癌胚抗原; 糖类抗原724; 糖类抗原199; 预后

Abstract：

Objective  To investigate the value of carcinoembryonic antigen (CEA), carbohydrate antigen 724 (CA724)and carbohydrate antigen 199 (CA199)as tumor markers in evaluating the prognosis of pancreatic cancer. Methods  From January 2012 to March 2013, 46 patients with pancreatic cancer who were treated surgically in the Fifth Affiliated Hospital of Xinjiang Medical University were selected. The levels of CEA, CA724 and CA199 were detected by radioimmunoassay 7 days, 1 month and 3 months after operation. The application effect of the above three tumor markers in evaluating the prognosis quality of pancreatic cancer treatment was analyzed. Results The expression of serum CEA, CA724 and CA199 in patients with pancreatic cancer at different stages were significantly different, all above normal levels. With the increase of clinical stages, the expression of serum CEA, CA724 and CA199 in patients with stage II and III were significantly higher than those in patients with stage I. The difference of data was statistically significant. Before operation, the serum CEA, CA724 and CA199 levels were significantly higher than the normal values. After 7 days, 1 month and 3 months of operation, the levels of patients' indicators were significantly lower than those before operation, with significant difference (P<0.05). The survival rate of patients with normal serum CEA, CA724 and CA199 levels at 3 months after operation was higher, and the difference was statistically significant. (P<0.05). Conclusion  The levels of CEA, CA724 and CA199 can be used as important indicators for evaluating the prognosis quality of pancreatic cancer patients, providing a reference for the formulation of follow-up treatment plans, and has further research value.

Key Words:  Tumor markers; Carcinoembryonic antigen; Carbohydrate antigen 724; Carbohydrate antigen 199; Prognosis