作者：蔡育志1，廖海华1，韩靖2，高剑1，刘丁一1，张彤1

单位：1.广州市番禺区中心医院 消化中心，广东 广州 511400； 2.广州市番禺区中心医院 病理科，广东 广州 511400

Authors:  CAI Yuzhi1, LIAO Haihua1, HAN Jing2, GAO Jian1, LIU Dingyi1, ZHANG Tong1

Unit:  1.Department of digestive center, Guangzhou Panyu Central Hospital, Guangzhou 511400, Guangdong, China； 2. Department of pathology, Guangzhou Panyu Central Hospital, Guangzhou 511400, Guangdong, China

摘要：

目的  探讨分析印痕位点调节因子样(brother of regulator of imprinted sites, BORIS)蛋白在结直肠癌中的表达情况及其预后意义。方法  通过免疫组织化学的方法分析BORIS蛋白在77例结直肠癌组织和20例癌旁正常组织中的表达,并分析BORIS的表达状态与结直肠癌患者的临床病理特点与患者预后的关系。结果  在癌旁正常组织中无BORIS蛋白表达,而在结直肠癌患者中BORIS的阳性率为66.2%。BORIS阳性更多见于以下患者:肿瘤直径较大、组织分化较差、进展期T分期、淋巴结转移和进展期TNM分期。BORIS阴性组的患者总体生存预后明显优于BORIS阳性组的患者,两组患者的5年生存率分别为73.1%和29.2%。多因素Cox回归分析的结果显示组织分化类型、T分期、远处转移和BORIS表达状态是影响本组结直肠癌患者的独立预后因素。结论  BORIS在结直肠组织中呈过表达状态,并与进展期TNM密切相关。BORIS可能可以作为结直肠患者的潜在预后预测指标。

关键词： BORIS; 结直肠癌; 临床病理特点; 预后

Abstract：

Objective  To investigate the expression and prognostic value of brother of regulator of imprinted sites (BORIS) in colorectal cancer. Methods  The expression of BORIS protein were analyzed by immunohistochemistry in 77 cases of colorectal cancer specimens and 20 cases of adjacent normal tissue of the patients with colorectal cancer. The correlation of BORIS expression with clinicopathologic factors and survival outcome of colorectal cancer patients were retrospectively evaluated. Results  No BORIS positive cases in the adjacent normal tissues and the BORIS positive rate of colorectal cancer tissues was 66.2%. The positive expression of BORIS was more likely to be found in patients with larger tumor size, poorly differentiated histological type, advanced T stage, lymph node metastasis and late TNM stage. The overall survival rate was significantly higher in the patients with BORIS negative group than the ones with BORIS positively group (5-year survival rate of BORIS negative and positive group was 73.1% and 29.2% respectively). Multivariate Cox regression analysis showed histological degree, T stage, distant metastasis and BORIS expression were the independent prognostic factors for colorectal patients in this study. Conclusion  BORIS was highly elevated in colorectal cancer tissues and it was associated with advanced TNM stage. BORIS was a potentially prognostic biomarker in colorectal cancer.

Key Words:  BORIS; Colorectal cancer; Clinicopathological feature; Prognosis