作者：李志豪1，姜泊2，迪吉1

单位：1.青海大学附属医院 肿瘤内科三病区，青海 西宁 810000； 2.清华大学北京清华长庚医院 消化内科，北京 102218

Authors:  Li Zhihao1，Jiang Bo1，Di Ji1

Unit: 1.Department of Oncology，Affiliated Hospital of Qinghai University，Xining 810000，Qinghai, China； 2.Department of Gastroenterology，Beijing Changgeng Hospital Tsinghua University，Beijing 102218，China

摘要：

微小RNAs（miRNAs）是一组小的非编码RNA，在胃癌中起着至关重要的作用。miRNAs通过靶基因mRNA产生双重的、相反的作用，即致癌或抑癌作用。致癌miRNAs在胃癌中过表达，并能抑制肿瘤抑制基因。相反，肿瘤抑制miRNAs在胃癌中表达通常下调，从而导致癌症的发展。异常表达的miRNAs参与胃癌的发生发展并调控不同的表型，如增殖、凋亡、转移及耐药性等。此外，miRNAs还可用于胃癌的诊断和预后预测等。本文综述了miRNAs在胃癌发展中的作用，以及miRNAs在诊断和预后中的潜在应用价值。

关键词：胃癌；miRNAs；增殖；转移；耐药；诊断；预后

Abstract：

MicroRNAs(miRNAs) are a group of small non coding RNAs, which play a crucial role in gastric cancer(GC). miRNAs produce carcinogenic or antitumor effects through target gene mRNA. Aberrantly expressed miRNAs, as tumor suppressor genes or oncogenes, participate in the occurrence and development of GC and regulate different phenotypes, such as proliferation, apoptosis, invasion and metastasis, and drug resistance. In addition, miRNAs can also be used for GC diagnosis and prognosis prediction. This article reviews the role of miRNAs in the development of GC and the potential application of miRNAs in diagnosis and prognosis.

Key Words:  Gastric cancer；MiRNAs；Proliferation；Metastasis；Drug resistance；Diagnosis；Prognosis