作者：易小江1,2，欧阳满照2

单位：1.广州中医药大学第二附属医院/广东省中医院 胃肠肿瘤中心 结直肠外科，广东 广州 510120； 2.南方医科大学顺德医院 胃肠外科，广东 佛山 528308

Authors:  Yi Xiaojiang 1,2，Ouyang Manzhao 2

Unit:  1. Gastrointestinal Cancer Center, Department of Colorectal Surgery, the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine/ Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong, China； 2. Department of Gastrointestinal Surgery, Shunde Hospital of Southern Medical University, Foshan 528308, Guangdong, China

摘要：

重楼主要的药理活性成分为皂苷类化合物。最近，重楼皂苷在抗肿瘤中的作用机制受到关注。既往研究发现重楼皂苷在诸多类型的肿瘤中能够抑制肿瘤细胞增殖和转移尧调控细胞周期、促进细胞凋亡和自噬，以及逆转肿瘤多药耐药。本文对不同重楼单体皂苷在结直肠癌抗肿瘤信号通路方面的研究进展进行分类总结，为发掘重楼单体皂苷中具有抗肿瘤作用且有安全成药潜质的成分提供参考。

关键词：重楼皂苷；抗肿瘤；信号通路；研究进展

Abstract：

Paris polyphylla main pharmacological active ingredients are saponins. Recently, the mechanism of Paris polyphylla saponin in anti-tumor has received hot attention. Previous studies have found that Paris polyphylla saponin can inhibit tumor cell proliferation and metastasis, regulate cell cycle, promote cell apoptosis and autophagy, and reverse multidrug resistance in many types of tumors. This paper classifies and summarizes the research progress of different parietal saponins in the anti-tumor signal pathway of colorectal cancer, so as to provide a reference for exploring the components with anti-tumor effect and potential for safe patent medicine.

Key Words:  Paris polyphylla saponin; Antitumor; Signal path; Research progress