作者：蔡修成1，刘永刚1，闫瑞娟1，魏海梁1，李京涛1，闫曙光2，常占杰1

单位：1.陕西中医药大学附属医院 肝病医院一病区，陕西 咸阳 712000；2.陕西中医药大学 第一临床医学院，陕西 咸阳 712000

Authors:  Cai Xiucheng1, Liu Yonggang1, Yan Ruijuan1, Wei Hailiang1, Li Jingtao1, Yan Shuguang2, Chang Zhanjie1

Unit:  1. Liver Disease Hospital Ward I, Affiliated Hospital of Shaanxi University of traditional Chinese medicine, Xianyang 712000, Shaanxi, China；2. The First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, Shaanxi, China

摘要：

肝细胞癌是世界范围内最常见且恶性程度最高的肿瘤之一，其发病机制尚未明确，致病原因颇多。通常认为肿瘤的形成是种子和土壤的相互作用，肝细胞癌中作为种子的肝肿瘤细胞受到土壤（肿瘤微环境）的不断刺激，最终形成肝细胞癌。在这个形成的过程中，肝肿瘤细胞内的介质如微泡（microvesicle, MV）参与细胞间信息与物质的传递，促进上皮向间充质转化（epithelial mesenchymal transition, EMT），推动肿瘤的侵袭与转移。本文综述了微泡与肿瘤微环境的密切关系，为肝细胞癌的治疗提供新的思路。

关键词： 肿瘤微环境；微泡；肝癌；上皮间质转化

Abstract：

Hepatocellular carcinoma is one of the most common and malignant tumors worldwide, and its pathogenesis is not yet clear, with many causes. It is generally believed that the formation of tumor is the interaction between seeds and soil. In hepatocellular carcinoma, the seeded liver tumor cells are constantly stimulated under the soil of tumor microenvironment, and eventually form hepatocellular carcinoma. During this formation process, mediators such as microvesicles within liver tumor cells participate in the transmission of information and substances between cells, promote epithelial mesenchymal transition (EMT), and promote tumor invasion and metastasis. This article reviews the close relationship between microvesicles and tumor microenvironment, which provides new ideas for the treatment of hepatocellular carcinoma.

Key Words:  Tumor microenvironment; Microvesicle; Liver cancer; Epithelial mesenchymal transition