作者：陆正闵，尚学琴

单位：云南大学附属医院 肿瘤科，云南 昆明 650021

Authors:  Lu Zhengmin, Shang Xueqin

Unit:  Department of Oncology, Yunnan University Affiliated Hospital, Kunming 650021, Yunnan, China

摘要：

T 细胞免疫球蛋白黏蛋白3（T-cell immunoglobulin mucin 3， TIM-3）是近年来被广泛研究的免疫调节蛋白，它在肿瘤的免疫治疗中具有重要的意义。TIM-3是属于TIM家族的Ⅰ型跨膜蛋白，其在多种免疫细胞和非免疫细胞中均有表达。TIM-3在机体免疫反应过程中起到负调节的作用，TIM-3与配体相互作用后可诱导T细胞凋亡，从而能够抑制免疫细胞的活性， 使肿瘤细胞能够逃避免疫系统的攻击。TIM-3已成为了肿瘤免疫治疗的一个关键靶点，联合阻断TIM-3和其他免疫检查点分子，可以增强T细胞的杀伤能力，进一步提高抗癌治疗的效果。本文就TIM-3与结直肠癌的发生发展、临床病理特征、预后及免疫治疗等的相关研究作一综述，探讨TIM-3作为结直肠癌免疫治疗靶点的重要地位及其临床价值。

关键词： 结直肠癌；T 细胞免疫球蛋白黏蛋白3；免疫逃逸；临床病理特征；预后；免疫治疗；综述

Abstract：

T-cell immunoglobulin mucin 3 (TIM-3) is an extensively studied immune regulatory protein in recent years and plays a crucial role in immunotherapy against cancer. TIM-3 is a type I transmembrane protein that belongs to the TIM family, and it is expressed in various immune and non-immune cells. Research has indicated that TIM-3 exerts negative regulation in the immune response of the body. The interaction between TIM-3 and its ligand can induce T-cell apoptosis, thus inhibiting the activity of immune cells and enabling cancer cells to evade immune attacks. TIM-3 has become a key target in cancer immunotherapy. By blocking TIM-3 in combination with other immune checkpoint molecules, the cytotoxicity of T-cells can be enhanced and further improve the effectiveness of the anti-cancer therapy. This review summarizes the research on the relationship between TIM-3 and colorectal cancer, including the occurrence and development of colorectal cancer, clinical pathological features, prognosis, and immune therapy. The review discusses the important role of TIM-3 as a therapeutic target for colorectal cancer immune therapy and its clinical significance.

Key Words:  Colorectal cancer; T-cell immunoglobulin mucin 3; Immune evasion; Clinical pathological features; Prognosis; Immune therapy; Review