作者：林淦1，黄嘉元1，何裕隆1,2，张华2，牟相宇1

Authors:  Lin Gan1, Huang Jiayuan1, He Yulong1,2, Zhang Hua2, Mou Xiangyu1

Unit:  1.Cancer for Infection and Immunity Studies, School of Medicine, Sun Yat -Sen University, Shenzhen 518107, Guangdong, China；2.Department of Digestive Medicine, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, Guangdong, China

摘要：

恶性肿瘤是当今医学界面临的一项重大挑战，是影响人类生命健康的重要因素。肠道菌群对肿瘤的发生、发展和药物疗效具有一定影响。随着基因测序技术和生物信息学的发展，研究者们相继在多种肿瘤中发现了细菌。常见的瘤内细菌有梭杆菌（Fusobacterium）、拟杆菌（Bacteroides）、普雷沃氏菌（Prevotella）等。作为肿瘤微环境中的组成部分，瘤内细菌可能对于肿瘤的增殖、转移以及耐药性产生影响，潜在的机制包括激活致癌通路、调节免疫反应、代谢药物等。本文针对瘤内细菌的新近研究展开综述，总结瘤内细菌特征与组成，探讨瘤内细菌与肿瘤的关联和作用，并为开发新的肿瘤治疗手段提供参考。

关键词： 瘤内细菌；肿瘤；肿瘤微环境

Abstract：

Malignant tumor is a serious medical challenge and an important factor affecting the health of humans. Tumor occurrence, development and drug efficacy are influenced by gut microbiota. Researchers have detected bacteria in various tumor consecutively. Common intratumoral bacteria genera include Fusobacterium, Bacteroides and Prevotella. As a composition of tumor microenvironment, intratumoral bacteria may influence tumor proliferation, metastasis and drug resistance. The potential mechanisms include activation of carcinogenic pathway, regulation of immune response, and drug metabolism. In this review, latest studies of intratumoral bacteria are summarized, including the characteristics and composition of intratumoral bacteria, and the association between intratumoral bacteria and tumors. This review provides a reference for the development of novel anti-cancer treatments targeting intratumoral bacteria.

Key Words:  Intratumoral bacteria; Tumor; Tumor-microenvironment